Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics
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چکیده
منابع مشابه
Soluble alpha klotho and its relation to kidney function and fibroblast growth factor-23
Alexandra Scholze, Ying Liu, Lise Pedersen, Shengqiang Xia, Heinz J. Roth, Berthold Hocher, Lars Melholt Rasmussen, and Martin Tepel Clinical Research Unit, Department of Nephrology, Odense University Hospital, Odense, Denmark; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Institute of Molecular Medicine, Cardiovascular and Renal Research, University of Southe...
متن کاملFibroblast growth factor 23/klotho axis in chronic kidney disease.
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates phosphate and 1,25-hydroxyvitamin D [1,25(OH)2D] metabolism. FGF23 binds to FGF receptor 1 with its coreceptor Klotho and maintains serum phosphate levels within the normal range by increasing renal phosphate excretion. In addition, FGF23 reduces the synthesis and accelerates the degradation of 1,25(OH)2D to reduce int...
متن کاملPathophysiological implications of fibroblast growth factor-23 and Klotho and their potential role as clinical biomarkers.
BACKGROUND Fibroblast growth factor-23 (FGF-23) and Klotho constitute the main regulatory system of phosphorus homeostasis. Beyond this physiological role, there is growing evidence suggesting that this system has relevant pathophysiological implications in different clinical processes. CONTENT In this review we discuss the pathophysiological implications of the FGF-23/Klotho system and the p...
متن کاملFibroblast growth factor 23 and soluble klotho in children with chronic kidney disease.
BACKGROUND Fibroblast growth factor 23 (FGF23), a bone-derived phosphaturic hormone, is elevated in chronic kidney disease (CKD). There are scarce data on the levels of its essential co-receptor klotho, and longitudinal changes in FGF23 levels are also unknown. METHODS We examined FGF23 and soluble klotho (s-klotho) levels over 1 year in 154 children with CKD Stages 1-5 (CKD1-5), were on dial...
متن کاملNeutrophil Gelatinase-Associated Lipocalin, Fibroblast Growth Factor 23, and Soluble Klotho in Long-Term Kidney Donors
BACKGROUND The best treatment for end-stage renal disease (ESRD) is kidney transplantation. Twenty-seven percent of transplantations in Norway are from living donors. Recent studies have shown an increased risk of ESRD and increased mortality in donors. The aim of this study was to determine if the levels of the new biomarkers neutrophil gelatinase-associated lipocalin (NGAL), soluble Klotho (s...
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ژورنال
عنوان ژورنال: Alcohol and Alcoholism
سال: 2017
ISSN: 0735-0414,1464-3502
DOI: 10.1093/alcalc/agx041